Fadogia agrestis

Black aphrodisiac

Forms: Stem extracts in capsules, often paired with tongkat ali in 'test booster' stacks.

SupplementsOver the counter (varies by country)Evidence: animal data only

A West African shrub used in Nigerian folk medicine as an aphrodisiac and promoted online as a testosterone booster. All evidence comes from rat studies; there are no human trials.

What it gives

What people use it for and what the sources report. Strength is a general category from the literature: mild, clear or strong.

Purpose

Used to raise testosterone and libido, based on rat studies showing higher testosterone and mating activity. The same group reported testicular, liver and kidney changes in rats; effects and safety in humans are unknown.

What people seek and what studies show

All evidence on its effects comes from rats, mostly from one Nigerian research group. A water extract of the stem raised blood testosterone and mating activity within days, and in rats with drug-induced erectile problems it restored penile nitric-oxide markers. Given for four weeks, it changed testicular enzymes in ways the authors judged harmful, with only partial recovery after stopping. No human studies exist.

Effects

No clear training effect in the sources.

Evidence: Animal data only — effects in people are unproven

Possible side effects

Possible does not mean certain: whether they appear depends on dose, duration, individual response and monitoring. Below — what to watch for and how to notice it early.

2 possible side effects

level · how often it is reported
Moderate
Unknown long-term safety (little human data)
No human studies at all; in rats it altered testicular function and raised markers of liver and kidney cell damage. Safety in people is unknown.
How to notice: Nothing to notice — the risk is what is not yet known.
possible
Moderate
Black-market quality risk (fakes, contamination)
In one analysis, 5 of 17 'fadogia' supplements contained none of the plant's marker compounds; Informed Sport or NSF testing screens for banned drugs, not the herb's own toxicity.
How to notice: Unexpected effects, pain or infection, a stronger or weaker effect than expected.
possible

What the levels mean

Lowbackground — just be aware
Moderatewatch for signs
Elevatedneeds regular control
Highcritical — can be life-threatening or permanent

Level: general category from the literature, not your personal risk

How often

common
reported often
possible
reported in some people
rare
reported occasionally

How to lower the risks

General ways to lower the chance of each side effect. No measure removes a risk completely.

ModerateUnknown long-term safety (little human data)

What is unknown cannot be lowered, only avoided; tell your doctor what you have taken.

ModerateBlack-market quality risk (fakes, contamination)

Products obtained without a prescription are often fake, mislabeled or non-sterile, and there is no way to check at home. For legal supplements, look for third-party testing (Informed Sport, NSF).

Check-ups and blood tests

Which tests and check-ups to do and when. This is a guide — agree the exact schedule with your doctor.

Baseline tests
your own starting values — every later result is compared with them
Liver panel (ALT, AST, GGT, bilirubin)
Kidney panel (creatinine, eGFR, cystatin C)
Testosterone (total, free), LH, FSH, SHBG
While taking
about 4–6 weeks in, then every 6–8 weeks — agree the exact schedule with your doctor
Liver panel (ALT, AST, GGT, bilirubin)
Kidney panel (creatinine, eGFR, cystatin C)
After stopping
4–8 weeks after stopping (later after long-acting injections), then until values return to baseline
Liver panel (ALT, AST, GGT, bilirubin)
Kidney panel (creatinine, eGFR, cystatin C)
Testosterone (total, free), LH, FSH, SHBG

Which doctors can help

Sports physiciancoordinates everything

Myth & fact

Myth

“Is fadogia a proven natural testosterone booster?”

Fact

No. The claim rests on rat studies, which also showed signs of testicular toxicity. Without human trials, neither benefit nor safety is known.

Combinations

No specific combination notes for this substance yet. The stack check still adds up side effects that several substances share.

Check combinations →

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