Arimistane (androsta-3,5-diene-7,17-dione)

Hormone control & recoveryNot approved for humansWADA S4 · prohibitedEvidence: anecdotal

A designer steroid, related to 7-keto-DHEA, sold in 'performance' supplements as an estrogen blocker. It was never developed as a medicine and has no human safety trials.

What it gives

What people use it for and what the sources report. Strength is a general category from the literature: mild, clear or strong.

Purpose

Marketed to steroid users and natural lifters to curb estrogen or 'boost testosterone', often after stopping steroids. It has no medical use; anti-doping labs list it as an aromatase inhibitor.

What people seek and what studies show

There are no studies of its effects or safety in people. The only human data are anti-doping studies in three volunteers given a single dose to identify its breakdown products; that single dose caused no relevant change in the urinary steroid profile. Whether it lowers estrogen or raises testosterone in humans is unproven.

Effects

Side-effect control

Evidence: Anecdotal — no real studies

Possible side effects

Possible does not mean certain: whether they appear depends on dose, duration, individual response and monitoring. Below — what to watch for and how to notice it early.

3 possible side effects

level · how often it is reported
Moderate
Black-market quality risk (fakes, contamination)
Sold only in unregulated supplements; the FDA's lab found it in performance products, and it has turned up unlabeled in a supplement sold as something else.
How to notice: Unexpected effects, pain or infection, a stronger or weaker effect than expected.
common
Moderate
Unknown long-term safety (little human data)
No human safety trials exist; short- and long-term effects on hormones, liver and heart are unknown.
How to notice: Nothing to notice — the risk is what is not yet known.
common
Low
Too-low estrogen (joints, libido, mood, lipids)
If it does block aromatase as marketed, estradiol may drop too low: aching joints, low libido, flat mood. Its real potency in humans is unmeasured.
How to notice: Aching, stiff joints, low libido, flat mood, poor sleep.
possible

What the levels mean

Lowbackground — just be aware
Moderatewatch for signs
Elevatedneeds regular control
Highcritical — can be life-threatening or permanent

Level: general category from the literature, not your personal risk

How often

common
reported often
possible
reported in some people
rare
reported occasionally

How to lower the risks

For 1 of 3 possible side effects there are specific ways to lower the chance: everyday measures, supplements and options a doctor may consider. For the rest — general advice. No measure removes a risk completely.

ModerateBlack-market quality risk (fakes, contamination)

Products obtained without a prescription are often fake, mislabeled or non-sterile, and there is no way to check at home. For legal supplements, look for third-party testing (Informed Sport, NSF).

ModerateUnknown long-term safety (little human data)

What is unknown cannot be lowered, only avoided; tell your doctor what you have taken.

Low-level side effects

Low estrogen
Avoid controlling estrogen blindly; adjust only by blood tests with a doctor.
Measure
Regular blood tests
How each option helps (1)
  • Regular blood tests — Testing ends guesswork use of aromatase inhibitors — prescription drugs that can push estrogen too low and harm joints, libido, mood and lipids.

Check-ups and blood tests

Which tests and check-ups to do and when. This is a guide — agree the exact schedule with your doctor.

Baseline tests
your own starting values — every later result is compared with them
Testosterone (total, free), LH, FSH, SHBG
Estradiol (sensitive assay)
While taking
about 4–6 weeks in, then every 6–8 weeks — agree the exact schedule with your doctor
Estradiol (sensitive assay)
After stopping
4–8 weeks after stopping (later after long-acting injections), then until values return to baseline
Testosterone (total, free), LH, FSH, SHBG

Which doctors can help

Sports physiciancoordinates everything

For women

Not studied in women; aromatase inhibitors act unpredictably before menopause, and supplements may contain undeclared steroids.

Myth & fact

Myth

“Arimistane is a natural, legal supplement ingredient.”

Fact

It is a designer steroid that the FDA's lab identified in performance supplements, it is prohibited in sport, and it has never been tested for safety in people.

Combinations

No specific combination notes for this substance yet. The stack check still adds up side effects that several substances share.

Check combinations →

Similar substances