Enclomiphene
Enclomifene, Enclomiphene citrate, Androxal, EnCyzix
The trans-isomer of clomiphene, without the long-acting estrogenic zuclomiphene. Raises LH, FSH and testosterone while preserving sperm production; not an approved medicine.
Legal status: Not approved as a medicine anywhere; unregulated products have no guaranteed content. Prohibited in sport at all times (WADA S4.2).
What it gives
What people use it for and what the sources report. Strength is a general category from the literature: mild, clear or strong.
Purpose
Studied in men with secondary hypogonadism as a way to raise testosterone without harming fertility; the FDA never approved it and the EMA refused it in 2018. In sport, used to try to speed recovery of natural testosterone after stopping steroids, a use that has not been studied.
What people seek and what studies show
In phase III trials in overweight men with secondary hypogonadism it restored normal testosterone and raised LH and FSH, while sperm counts stayed normal; on testosterone gel they fell markedly. Still, the EMA found no proven clinical benefit: improvement in symptoms, body fat, muscle or strength was not shown, and these outcomes were largely not measured.
Effects
Evidence: Limited human data — some human studies, small or short
Possible side effects
Possible does not mean certain: whether they appear depends on dose, duration, individual response and monitoring. Below — what to watch for and how to notice it early.
4 possible side effects
level · how often it is reportedWhat the levels mean
Level: general category from the literature, not your personal risk
How often
- common
- reported often
- possible
- reported in some people
- rare
- reported occasionally
How to lower the risks
For 2 of 4 possible side effects there are specific ways to lower the chance: everyday measures, supplements and options a doctor may consider. For the rest — general advice. No measure removes a risk completely.
Check the blood count regularly; if hematocrit stays high, a doctor decides — usually stopping or reducing the cause, sometimes therapeutic phlebotomy, never blood-bank donation. Avoid dehydration: it thickens the blood further.
How each option helps (3)
- Regular blood tests — A blood count shows hematocrit and hemoglobin climbing toward the range where clot and stroke risk rises.
- Therapeutic phlebotomy prescribed by a doctor — Only on a doctor's decision, never at a blood bank. Lowers hematocrit quickly but temporarily; repeated sessions drain iron, and a lower clot risk is unproven.
- Working with a doctor — Manages thick blood by changing what you use or, if justified, by therapeutic phlebotomy.
Products obtained without a prescription are often fake, mislabeled or non-sterile, and there is no way to check at home. For legal supplements, look for third-party testing (Informed Sport, NSF).
Stop and see an ophthalmologist at any vision change.
How each option helps (1)
- Working with a doctor — Vision changes on clomiphene, tamoxifen, isotretinoin, PDE5 or GLP-1 drugs need prompt review; several labels advise stopping, which may limit lasting harm.
Low-level side effects
Check-ups and blood tests
Which tests and check-ups to do and when. This is a guide — agree the exact schedule with your doctor.
Which doctors can help
Get medical help at once if
- Swelling, pain or redness in one leg; sudden shortness of breath or chest pain; sudden one-sided weakness or numbness, trouble speaking or seeing — seek urgent care.
- Sudden loss or blurring of vision, flashes, a curtain over sight — seek urgent care.
In an emergency, call your local emergency number.
Myth & fact
“Enclomiphene is clomiphene without the side effects.”
Without zuclomiphene, mood and libido complaints appear less often, but it is still a SERM: regulators flagged clot risk, and long-term data are missing.
Combinations
While anabolic steroids are being taken, these drugs cannot restore natural testosterone production: the steroids keep LH switched off. Their side effects still apply.
ClomipheneSources
Possible side effects by body system, combinations, how to lower the risks and which tests to do — free.
Open the stack check