Stenabolic (SR9009)
SR-9009
A Rev-ErbA agonist, not a SARM, from the Scripps Research Institute that alters the body clock and metabolism in mice; never tested in humans.
Legal status: Never approved or tested in humans; sold as a 'research chemical' and prohibited at all times in sport as a metabolic modulator.
What it gives
What people use it for and what the sources report. Strength is a general category from the literature: mild, clear or strong.
Purpose
Taken for endurance and fat loss, based on mouse studies showing higher energy expenditure and running capacity. It has never been studied in humans, so whether it works in people at all is unknown.
What people seek and what studies show
In mice given it by injection, REV-ERB activation raised energy expenditure, cut fat mass and improved blood sugar and lipids, and Rev-erbα activity is tied to mitochondrial number and exercise capacity. But in mice engineered without both REV-ERB proteins it still altered cell metabolism and viability, so its effects are not specific to the target it is sold for. Nothing is known about it in humans.
Effects
Evidence: Animal data only — effects in people are unproven
Sought effects by goal (as reported)
Possible side effects
Possible does not mean certain: whether they appear depends on dose, duration, individual response and monitoring. Below — what to watch for and how to notice it early.
4 possible side effects
level · how often it is reportedWhat the levels mean
Level: general category from the literature, not your personal risk
How often
- common
- reported often
- possible
- reported in some people
- rare
- reported occasionally
How to lower the risks
For 2 of 4 possible side effects there are specific ways to lower the chance: everyday measures, supplements and options a doctor may consider. For the rest — general advice. No measure removes a risk completely. Prescription medicines are listed only for a doctor to decide on, after tests — they have side effects of their own.
No alcohol, no other liver stressors, limit oral steroids and their combinations, check liver enzymes.
How each option helps (6)
- Avoiding alcohol and other liver stressors — Removes a major extra liver stressor during oral steroids and other hepatotoxic drugs.
- Regular blood tests — ALT, AST, GGT and bilirubin show liver strain before symptoms; heavy lifting alone raises AST/ALT for days, and GGT helps tell muscle from liver.
- Ademetionine (SAMe) — Used for intrahepatic cholestasis in some countries, but trials are small and of low quality; untested in steroid users. Stopping the oral steroid matters most.
- N-acetylcysteine (NAC) — Restores glutathione; proven in paracetamol poisoning and helped in early acute liver failure of other causes, but untested in steroid users.
- TUDCA (tauroursodeoxycholic acid) — Improves bile flow in cholestatic disease; in steroid cholestasis only case reports, with failures in severe cases. Stopping the oral steroid matters most.
- Ursodeoxycholic acid (UDCA) — A doctor may consider it to improve bile flow; in steroid cholestasis benefit is unproven and severe cases often did not respond. Stopping the oral steroid comes first. Has side effects of its own.
Products obtained without a prescription are often fake, mislabeled or non-sterile, and there is no way to check at home. For legal supplements, look for third-party testing (Informed Sport, NSF).
What is unknown cannot be lowered, only avoided; tell your doctor what you have taken.
Low-level side effects
How each option helps (5)
- Sleep hygiene — A steady routine and no late caffeine ease stimulant- and steroid-related insomnia; night sweats on trenbolone persist regardless.
- Glycine — Small trials show slightly better sleep quality and less next-day fatigue; not a sedative and not for anxiety.
- L-theanine — Small gain in subjective sleep quality; effects on anxiety are inconsistent. May smooth caffeine jitters but won't offset strong stimulants like clenbuterol.
- Magnesium — Three small, low-quality trials in older adults: falling asleep about 17 minutes sooner. No good data in athletes.
- Melatonin — Helps you fall asleep a little faster, especially with a shifted body clock; does not treat anxiety or night sweats.
Check-ups and blood tests
Which tests and check-ups to do and when. This is a guide — agree the exact schedule with your doctor.
Which doctors can help
Get medical help at once if
- Yellow skin or eyes, dark urine, pale stools, intense itching, pain under the right ribs — see a doctor now; sudden severe abdominal pain with dizziness or fainting — call emergency services.
In an emergency, call your local emergency number.
For women
Non-hormonal, so no virilization is expected, but there are no safety data in women, or in anyone else.
Myth & fact
“SR9009 is 'exercise in a pill'.”
That label comes from mouse experiments. There are no human studies, nobody knows whether it works in people at all, and its effects aren't even specific to its target.
Combinations
No specific combination notes for this substance yet. The stack check still adds up side effects that several substances share.
Sources
Possible side effects by body system, combinations, how to lower the risks and which tests to do — free.
Open the stack check