Quinbolone

Anabolicum Vister, Boldenone cyclopentenyl ether

Forms: Injectable boldenone — undecylenate (Equipoise), cypionate and acetate — has its own cards.

Other esters and forms: Boldenone undecylenate, Boldenone acetate, Boldenone cypionate

Oral steroidsControlled substanceWADA S1.1 · prohibitedEvidence: limited human data

An oral form of boldenone: its 17-cyclopentenyl ether, once sold as Anabolicum Vister. Unlike most oral steroids it is not 17α-alkylated. Human data are old and sparse.

What it gives

What people use it for and what the sources report. Strength is a general category from the literature: mild, clear or strong.

Purpose

Sought as an oral boldenone. Italian studies from the 1960s to 1980 looked at it for anemia in dialysis patients, in older women and in children; its human metabolism after oral intake was described in 1971. Modern data do not exist.

What people seek and what studies show

Old Italian studies, mostly without English abstracts, looked at weight, red cells and pituitary hormones. In a comparison for hereditary angioedema it did not prevent attacks, unlike the 17α-alkylated danazol and stanozolol. How strong its muscle effects are in people is unknown.

Effects

Muscle growthStrength

Evidence: Limited human data — some human studies, small or short

Sought effects by goal (as reported)

Mass
Sought for: muscle growth, strength
Recomposition
Sought for: muscle growth
Strength
Sought for: strength, muscle growth
Works against it: tendon / ligament injury risk

Possible side effects

Possible does not mean certain: whether they appear depends on dose, duration, individual response and monitoring. Below — what to watch for and how to notice it early.

15 possible side effects

level · how often it is reported
Elevated
Suppression of natural testosterone & fertility
Expected to suppress natural testosterone and sperm production like other AAS; old Italian studies examined pituitary hormones on it, but modern data are lacking.
How to notice: Lower libido and energy, smaller testicles; after stopping — low natural testosterone on tests, often with tiredness and low mood.
In women: Menstrual changes or missed periods, lower libido and energy; reduced fertility.
common
Moderate
Black-market quality risk (fakes, contamination)
Tablets or capsules sold under this name have uncertain origin and content; there are no modern quality or safety data on them.
How to notice: Unexpected effects, pain or infection, a stronger or weaker effect than expected.
common
Moderate
Worse cholesterol (HDL↓ LDL↑)
Expected to lower HDL like other AAS; there are no specific data, so only a lipid panel shows it.
How to notice: No symptoms — only visible on a lipid panel.
possible
Moderate
Thick blood (hematocrit) / clot risk
Studied for anemia in dialysis patients, where raising red cells is the aim; in a healthy athlete it thickens the blood, more so with dehydration from weight cuts or heat.
How to notice: Often silent; sometimes headaches, flushed face, itch after a hot shower.
possible
Moderate
Higher blood pressure
Androgens can raise blood pressure, usually without symptoms; home readings at rest, not right after training, show the trend.
How to notice: Often silent; sometimes headaches, flushing, nosebleeds — a home monitor shows it. Heavy lifts briefly spike it even in healthy lifters.
possible
Moderate
Heart strain / heart-muscle thickening
No compound data; long-term steroid-using lifters pumped weaker than non-using lifters (LVEF 52% vs 63%) and had more coronary plaque — not 'athlete's heart'.
How to notice: Shortness of breath on effort, endurance falling for no training reason, palpitations.
possible
Moderate
Low mood, depression, lethargy
Class effect: after stopping, while the body's own testosterone is still suppressed, low mood, fatigue and low libido can follow; a doctor can help.
How to notice: Flat mood, low motivation, tiredness; can follow stopping androgens. Overtraining or RED-S can look the same.
possible
Moderate
Tendon / ligament injury risk
Class data: steroid-using bodybuilders had about 9 times more tendon ruptures than non-using lifters, upper-body ones only in users; a quarter followed local pain.
How to notice: Pain at tendon attachments under heavy load; in steroid-using bodybuilders about a quarter of ruptures followed such pain.
possible
Moderate
Unknown long-term safety (little human data)
Long-term human safety was never studied beyond small reports from the 1970s–80s; known risks are borrowed from boldenone and other AAS.
How to notice: Nothing to notice — the risk is what is not yet known.
possible
Moderate
Kidney strain
Boldenone has raised creatinine without kidney disease, as muscle mass, training and creatine can; cystatin C and a urine test help tell this from real AAS kidney damage.
How to notice: Usually silent; foamy urine or swelling in later stages. Big muscle mass or creatine also raise creatinine.
rare
MenLow
WomenHigh
Virilization in women (often irreversible)
In women it causes voice deepening, facial hair and clitoral enlargement, which may be permanent.
How to notice: Hoarse or deeper voice, new facial or body hair, menstrual changes, clitoral enlargement.
common
Low
High estrogen (water, gyno risk)
Converts to estrogen less than testosterone; estrogenic effects such as water retention are usually milder but possible.
How to notice: Puffiness, sensitive or itchy nipples, mood swings, water weight.
possible
Low
Anxiety, insomnia, night sweats
Some boldenone users report anxiety and restlessness; the evidence is anecdotal, and there are no reports for this oral form.
How to notice: Trouble falling asleep, night sweats, restlessness; poor sleep lowers training quality and recovery.
possible
Low
Acne, oily skin
Acne and oily skin are possible, as with other androgens.
How to notice: Oily skin, spots on back, shoulders and face.
possible
Low
Androgenic hair loss
Only weakly converted to a DHT-like androgen; hair loss is possible in those genetically prone.
How to notice: More hair in the shower, thinning at the temples or crown.
possible

What the levels mean

Lowbackground — just be aware
Moderatewatch for signs
Elevatedneeds regular control
Highcritical — can be life-threatening or permanent

Level: general category from the literature, not your personal risk

How often

common
reported often
possible
reported in some people
rare
reported occasionally

How to lower the risks

For 12 of 15 possible side effects there are specific ways to lower the chance: everyday measures, supplements and options a doctor may consider. For the rest — general advice. No measure removes a risk completely. Prescription medicines are listed only for a doctor to decide on, after tests — they have side effects of their own.

ElevatedSuppression of natural testosterone & fertility

Check hormones before and after; if they stay low, see an endocrinologist. Hard training on too little food (RED-S) also lowers testosterone.

How each option helps (8)
  • Regular blood tests — LH, FSH and testosterone show how deep suppression is and whether natural production has recovered afterwards.
  • Working with a doctor — Assesses how deep suppression is and guides recovery afterwards, including fertility testing.
  • Choriogonadotropin alfa (recombinant hCG) — A doctor may consider it off-label to preserve fertility (it keeps the testes working); it does not restart the pituitary. Risks: higher estradiol, gynecomastia. Has side effects of its own.
  • Clomiphene — A doctor may consider it after stopping, guided by hormone tests; most men recover on their own within months, and lasting benefit is unproven. Risks: vision changes, mood swings, rare clots. Has side effects of its own.
  • hCG (urinary human chorionic gonadotropin) — A doctor may consider it to preserve fertility (in men it keeps the testes working); it does not restart the pituitary, so natural LH still has to recover. Risks: higher estradiol, gynecomastia. Has side effects of its own.
  • Tamoxifen — A doctor may consider it after steroids are stopped, guided by hormone tests; it has not been tested for this after steroid use. Risks: blood clots, vision changes. Has side effects of its own. Not offered to women: in the women’s view it adds to a risk this substance already carries.
  • Follicle-stimulating hormone (follitropins, menotropins) — A fertility doctor may consider adding it to hCG when semen tests and FSH stay low; it does not restart the pituitary. Risks: gynecomastia, acne. Has side effects of its own.
  • Toremifene — A doctor may consider it after steroids are stopped, guided by hormone tests; it raised testosterone in subfertile men but was never tested after steroids. Risks: QT prolongation, clots. Has side effects of its own. Not offered to women: in the women’s view it adds to a risk this substance already carries.
ModerateBlack-market quality risk (fakes, contamination)

Products obtained without a prescription are often fake, mislabeled or non-sterile, and there is no way to check at home. For legal supplements, third-party testing (Informed Sport, NSF) lowers, but does not remove, the risk of a positive doping test.

ModerateWorse cholesterol (HDL↓ LDL↑)

Avoid combining several oral steroids; regular cardio, soluble fiber (psyllium), less saturated fat and alcohol; if LDL/ApoB stay high, a doctor may consider a statin. Omega-3 only lowers triglycerides.

Measure
Regular blood testsWorking with a doctorAvoiding alcohol and other liver stressorsRegular cardio training
How each option helps (8)
  • Regular blood tests — A lipid panel with ApoB shows how far HDL has dropped and LDL risen — changes you cannot feel.
  • Working with a doctor — Interprets lipids and ApoB and decides whether a statin or other therapy is warranted.
  • Avoiding alcohol and other liver stressors — Alcohol raises triglycerides; its small HDL bump does not lower heart risk.
  • Regular cardio training — Raises HDL a little and lowers triglycerides; it cannot offset a steroid-driven fall in HDL on its own.
  • Berberine — Placebo-controlled meta-analysis: LDL about 0.5 and triglycerides about 0.4 mmol/L lower; HDL unchanged. Trials are mostly small; no statin substitute.
  • Citrus bergamot — Pooled small trials show lower LDL and triglycerides, but certainty is low to very low; it is no replacement for statins.
  • Omega-3 (fish oil, EPA/DHA) — Lowers triglycerides but does not fix the steroid HDL drop, the main lipid harm; omega-3 supplements may even raise LDL (IOC).
  • Psyllium husk fiber — Lowers LDL by about 0.2–0.3 mmol/L (roughly 5–10%), also on top of doctor-prescribed statins; no effect on HDL.
ModerateThick blood (hematocrit) / clot risk

Check the blood count regularly; if hematocrit stays high, a doctor decides — usually stopping or reducing the cause, sometimes therapeutic phlebotomy, never blood-bank donation. Dehydration in long or hot sessions and long flights add to clot risk.

Measure
Regular blood testsTherapeutic phlebotomy prescribed by a doctorWorking with a doctor
How each option helps (3)
  • Regular blood tests — A blood count shows hematocrit and hemoglobin climbing toward the range where clot and stroke risk rises.
  • Therapeutic phlebotomy prescribed by a doctor — Only on a doctor's decision, never at a blood bank. Lowers hematocrit quickly but temporarily; repeated sessions drain iron, and a lower clot risk is unproven.
  • Working with a doctor — Manages thick blood by changing what you use or, if justified, by therapeutic phlebotomy; dehydration, long flights and injury immobilization add to clot risk in athletes.
ModerateHigher blood pressure

Less salt, regular cardio, good sleep, home readings; if it stays high — a doctor, and a talk about maximal lifts.

How each option helps (19)
  • Home blood-pressure monitoring — Persistently high resting readings mean seeing a doctor. For athletes, guidance prefers ARBs or ACE inhibitors, which don't limit exercise capacity; diuretics are banned in sport.
  • Regular cardio training — In a meta-analysis of trials, endurance training lowered resting BP by about 8/5 mmHg in people with high BP and only slightly in those with normal BP.
  • Working with a doctor — Diagnoses persistent hypertension and prescribes treatment when needed.
  • Avoiding alcohol and other liver stressors — Regular drinking raises blood pressure; cutting it out lowers it.
  • Coenzyme Q10 — Inconsistent: some analyses show a small systolic drop in cardiometabolic disease, but a Cochrane review found no clinically meaningful effect.
  • Magnesium — Meta-analysis of 34 trials in adults, not athletes: about 2 mmHg lower systolic pressure on average.
  • Magnesium aspartate — On average magnesium lowers blood pressure only slightly — not a substitute for a doctor's assessment of high pressure found at a sports check.
  • Magnesium chloride — On average magnesium lowers blood pressure only slightly — not a substitute for a doctor's assessment of high pressure found at a sports check.
  • Magnesium citrate — On average magnesium lowers blood pressure only slightly — not a substitute for a doctor's assessment of high pressure found at a sports check.
  • Magnesium gluconate — On average magnesium lowers blood pressure only slightly — not a substitute for a doctor's assessment of high pressure found at a sports check.
  • Magnesium glycinate (bisglycinate) — On average magnesium lowers blood pressure only slightly — not a substitute for a doctor's assessment of high pressure found at a sports check.
  • Magnesium lactate — On average magnesium lowers blood pressure only slightly — not a substitute for a doctor's assessment of high pressure found at a sports check.
  • Magnesium malate — On average magnesium lowers blood pressure only slightly — not a substitute for a doctor's assessment of high pressure found at a sports check.
  • Magnesium orotate — On average magnesium lowers blood pressure only slightly — not a substitute for a doctor's assessment of high pressure found at a sports check.
  • Magnesium oxide — On average magnesium lowers blood pressure only slightly — not a substitute for a doctor's assessment of high pressure found at a sports check.
  • Magnesium taurate — Meta-analysis of trials: about 2 mmHg lower systolic pressure on average — too small to replace a doctor's assessment of high pressure found at a sports check.
  • Omega-3 (fish oil, EPA/DHA) — Small drop of a few mmHg, mainly in people with untreated high blood pressure.
  • Potassium — Meta-analysis of trials: about 3.5 mmHg lower systolic pressure on average, seen only in people with hypertension.
  • Taurine — Meta-analysis of 20 small trials: about 4 mmHg lower systolic pressure on average.
ModerateHeart strain / heart-muscle thickening

Regular cardio, blood pressure control, an echo as a baseline and then yearly, read by a cardiologist who knows athletes’ hearts.

Measure
Heart screening: ECG and echocardiogramWorking with a doctorHome blood-pressure monitoringRegular cardio training
How each option helps (4)
  • Heart screening: ECG and echocardiogram — Echocardiography shows wall thickening and reduced pumping early, while stopping AAS and treating BP can still help.
  • Working with a doctor — Orders ECG and echocardiography and treats early heart changes.
  • Home blood-pressure monitoring — Keeping BP controlled is one of the main ways to limit heart-wall thickening.
  • Regular cardio training — Supports heart and vessel function, but does not reverse steroid-related heart thickening or weakening.
ModerateLow mood, depression, lethargy

Keep routine and social contact; talk to a specialist if low mood persists; a sports physician can check for overtraining and RED-S.

Measure
Working with a doctorSleep hygiene
How each option helps (2)
  • Working with a doctor — Mood problems, including the low after stopping steroids, are treatable; a doctor can refer you to mental-health care.
  • Sleep hygiene — Good sleep supports mood, especially in the low-hormone phase after stopping steroids.
ModerateTendon / ligament injury risk

Progress weights gradually — strength rises faster than tendons adapt; with persistent tendon pain, cut the load and see a sports physician.

ModerateUnknown long-term safety (little human data)

What is unknown cannot be lowered, only avoided; tell your doctor what you have taken.

ModerateKidney strain

Drink enough, more in heat; control blood pressure; avoid regular painkillers (NSAIDs) and any during long or hot events; no weight cutting by dehydration.

Measure
Fluid & electrolyte managementRegular blood testsWorking with a doctor
How each option helps (3)
  • Fluid & electrolyte management — Good hydration eases kidney stress from heavy training and heat; dehydration plus NSAIDs is a classic cause of acute kidney injury.
  • Regular blood tests — Creatinine runs high with big muscle mass, creatine and hard training, and standard eGFR formulas mislead in athletes; compare with your own baseline and add cystatin C and urinalysis.
  • Working with a doctor — Investigates protein in the urine or falling kidney function and can start treatment that slows kidney damage.
MenLow
WomenHigh
Virilization in women (often irreversible)

Stop at the first voice change and see a doctor — early stopping matters.

Measure
Working with a doctor
How each option helps (1)
  • Working with a doctor — Steroid labels say to stop at the first mild signs (hoarse voice, facial hair, clitoral growth) to prevent permanent change; checks catch them early but do not make use safe.

Low-level side effects

High estrogen
Check estradiol by blood test before acting on symptoms; keep salt and body fat in check.
Measure
Regular blood testsWorking with a doctor
How each option helps (2)
  • Regular blood tests — A sensitive estradiol test shows whether water retention or nipple tenderness really comes from high estrogen.
  • Working with a doctor — Prescription estrogen control is safer when adjusted by lab results than by guesswork.
Sleep & anxiety
Sleep routine, no stimulants or caffeine (pre-workouts too) late in the day, magnesium or melatonin; late sessions and travel also disturb sleep.
How each option helps (16)
  • Sleep hygiene — A steady routine and no late caffeine ease stimulant- and steroid-related insomnia; night sweats on trenbolone persist regardless.
  • Glycine — Small trials show slightly better sleep quality and less next-day fatigue; not a sedative and not for anxiety.
  • L-theanine — Small gain in subjective sleep quality; effects on anxiety are inconsistent. May smooth caffeine jitters but won't offset strong stimulants like clenbuterol.
  • Magnesium — Three small, low-quality trials in older adults: falling asleep about 17 minutes sooner. No good data in athletes.
  • Magnesium aspartate — In active men a zinc–magnesium aspartate product did not change measured sleep; in older adults three small trials found falling asleep about 17 minutes sooner.
  • Magnesium chloride — Three small, low-quality trials in older adults: falling asleep about 17 minutes sooner. No good sleep trials in athletes.
  • Magnesium citrate — Evidence that it improves sleep is weak, and there are no good sleep trials in athletes.
  • Magnesium gluconate — Evidence that it improves sleep is weak, and there are no good sleep trials in athletes.
  • Magnesium glycinate (bisglycinate) — In 155 adults with poor sleep, self-rated insomnia improved slightly more than on placebo (small effect). No data in athletes; it does not replace sleep habits.
  • Magnesium L-threonate — Small industry-funded trials: some self-rated sleep measures improved; one found no change in tracker-measured sleep. No data in athletes.
  • Magnesium lactate — Three small, low-quality trials in older adults: falling asleep about 17 minutes sooner. No good sleep trials in athletes.
  • Magnesium malate — Three small, low-quality trials in older adults: falling asleep about 17 minutes sooner. No good sleep trials in athletes.
  • Magnesium orotate — Evidence that it improves sleep is weak, and there are no good sleep trials in athletes.
  • Magnesium oxide — Evidence that it improves sleep is weak, and there are no good sleep trials in athletes.
  • Magnesium taurate — Three small, low-quality trials in older adults: falling asleep about 17 minutes sooner. No good sleep trials in athletes.
  • Melatonin — Helps you fall asleep a little faster, especially with a shifted body clock; does not treat anxiety or night sweats.
Acne
Gentle skin care, cleansing after training, a dermatologist if it spreads.
Supplement or OTC product
How each option helps (3)
  • Adapalene — Reduces spots in many users. Redness, scaling, dryness and stinging are common early and usually ease; acne may look worse at first. Rarely, allergic swelling.
  • Benzoyl peroxide — A first-line acne option. Dryness, redness and peeling are common at first; it bleaches hair, towels and training clothes; rarely, serious allergy. Severe steroid acne needs a dermatologist.
  • Zinc — Trials show a modest drop in inflamed spots, weaker than antibiotics; steroid acne is driven by androgens.
Hair loss
Ketoconazole shampoo, minoxidil, a dermatologist early if you are prone to it.
Supplement or OTC product
How each option helps (1)
  • Minoxidil (topical) — Slows thinning and regrows some hair; scalp itching and early temporary shedding are common, unwanted facial hair possible. Gains fade once stopped.

Check-ups and blood tests

Which tests and check-ups to do and when. This is a guide — agree the exact schedule with a sports physician.

Baseline tests
your own starting values — every later result is compared with them
Lipid panel (HDL, LDL, triglycerides, ApoB)In athletes, a high LDL can also be a sign of too little food for the training (RED-S) — tell the doctor about dieting.cholesterol
Complete blood count (hematocrit, hemoglobin)Endurance training dilutes the blood (“sports anemia”), dehydration concentrates it — test hydrated and rested, against your own baseline.hematocrit
Kidney panel (creatinine, eGFR, cystatin C)Creatinine reads higher with big muscle mass or creatine; cystatin C barely depends on muscle and helps judge the kidneys in athletes.blood pressure, kidneys
Testosterone (total, free), LH, FSH, SHBGTestosterone also falls with hard training on too little food (RED-S) — test in the morning, rested, and tell the doctor about dieting.natural testosterone, low mood
Estradiol (sensitive assay)
Home blood-pressure logMeasure seated and rested, not within 30 minutes after training, caffeine or smoking — they change the reading.blood pressure, heart, kidneys
ECGTraining changes the ECG in ways that are normal for athletes; ask for a reading by the international athlete criteria, which separate these from disease.heart
Echocardiogram (heart ultrasound)Weight training alone does not weaken the heart’s pumping or relaxation; in a lifter that is not “athlete’s heart” — in steroid users it was linked to the drugs.heart
UrinalysisHard exercise can briefly put protein and blood into the urine, usually gone within a few days — test after rest and repeat before drawing conclusions.kidneys
While taking
about 4–6 weeks in, then every 6–8 weeks — agree the exact schedule with your doctor
Lipid panel (HDL, LDL, triglycerides, ApoB)In athletes, a high LDL can also be a sign of too little food for the training (RED-S) — tell the doctor about dieting.cholesterol
Complete blood count (hematocrit, hemoglobin)Endurance training dilutes the blood (“sports anemia”), dehydration concentrates it — test hydrated and rested, against your own baseline.hematocrit
Kidney panel (creatinine, eGFR, cystatin C)Creatinine reads higher with big muscle mass or creatine; cystatin C barely depends on muscle and helps judge the kidneys in athletes.blood pressure, kidneys
Estradiol (sensitive assay)
Home blood-pressure logMeasure seated and rested, not within 30 minutes after training, caffeine or smoking — they change the reading.blood pressure, heart, kidneys
UrinalysisHard exercise can briefly put protein and blood into the urine, usually gone within a few days — test after rest and repeat before drawing conclusions.kidneys
After stopping
4–8 weeks after stopping (later after long-acting injections), then until values return to baseline
Lipid panel (HDL, LDL, triglycerides, ApoB)In athletes, a high LDL can also be a sign of too little food for the training (RED-S) — tell the doctor about dieting.cholesterol
Complete blood count (hematocrit, hemoglobin)Endurance training dilutes the blood (“sports anemia”), dehydration concentrates it — test hydrated and rested, against your own baseline.hematocrit
Kidney panel (creatinine, eGFR, cystatin C)Creatinine reads higher with big muscle mass or creatine; cystatin C barely depends on muscle and helps judge the kidneys in athletes.blood pressure, kidneys
Testosterone (total, free), LH, FSH, SHBGTestosterone also falls with hard training on too little food (RED-S) — test in the morning, rested, and tell the doctor about dieting.natural testosterone, low mood
Semen analysisnot earlier than 3 months after stopping, then every 3 months until normalnatural testosterone
Every year
with regular or repeated use
ECGTraining changes the ECG in ways that are normal for athletes; ask for a reading by the international athlete criteria, which separate these from disease.heart
Echocardiogram (heart ultrasound)Weight training alone does not weaken the heart’s pumping or relaxation; in a lifter that is not “athlete’s heart” — in steroid users it was linked to the drugs.heart

Which doctors can help

Cardiologistcholesterol, blood pressure, hematocrit, heart
Endocrinologistnatural testosterone
Nephrologistkidneys
Psychotherapist / psychiatristlow mood
Sports physiciantendons
Gynecologistvirilization, natural testosterone (women)

At home

  • Home blood pressure: 2–3 times a week in the morning, keep a log

Get medical help at once if

  • Sudden severe headache, vision changes, numbness or weakness on one side, trouble speaking — call your local emergency number.
  • Swelling, pain or redness in one leg (especially after a long flight) — urgent care; sudden breathlessness, chest pain, one-sided weakness or numbness, trouble speaking or seeing — call your local emergency number.
  • Chest pain or pressure, fainting or near-fainting on exertion, breathlessness on light effort, swollen ankles — stop training and seek urgent care; collapse — call your local emergency number.
  • Much less urine than usual, cola-colored urine (especially with severe muscle pain after hard training), new swelling, flank pain — see a doctor now.
  • Thoughts of suicide or self-harm — call your local emergency number or a crisis line right now.
  • A snap and sudden sharp pain in a tendon, inability to load the limb — stop training and get it examined.
  • Deepening voice, new facial hair, clitoral enlargement — stop and see a doctor: changes can become permanent. (women)

In an emergency, call your local emergency number.

For women

Old Italian studies included older women, but no modern safety data exist. As an androgen it can cause voice deepening, facial hair and clitoral enlargement, which may be permanent. In women athletes, hoarseness, new facial hair and menstrual changes are early signs.

Myth & fact

Myth

“An oral steroid that isn't 17α-alkylated is harmless.”

Fact

Without 17α-alkylation liver strain may be lower, but it still acts as an androgen: suppression of natural testosterone, lower HDL and, in women, virilization are expected. Modern safety data do not exist.

Combinations

No specific combination notes for this substance yet. The stack check still adds up side effects that several substances share.

Check combinations →

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