Gestrinone
R-2323, R2323, Ethylnorgestrienone, Dimetriose, Nemestran, Gestrinona, Chip da beleza, Chip de gestrinona
Forms: Oral capsules for endometriosis (e.g. Dimetriose, Nemestran) in some countries; vaginal use was studied. In Brazil, compounded implants under the skin ('chip da beleza'), often mixed with other hormones.
A 19-nortestosterone derivative with androgenic, anabolic, antiprogestogenic and antiestrogenic action, approved in some countries for endometriosis. The designer steroid THG was made from it.
Legal status: Prescription medicine for endometriosis in some countries; Brazil controls it as an anabolic and suspended compounded implants; status varies by country.
What it gives
What people use it for and what the sources report. Strength is a general category from the literature: mild, clear or strong.
Purpose
Promoted, mostly to women, as an implant under the skin ('beauty chip') for muscle gain, fat loss and libido. Medically used for endometriosis. In Brazil the Federal Council of Medicine banned prescribing anabolic steroids for looks, and the drug regulator suspended compounded implants.
What people seek and what studies show
Trial data come from women treated for endometriosis, fibroids or contraception. Evidence for muscle gain or fat loss is lacking: in a review of 32 trials most studies found weight gain (0.9–8 kg per patient), and no trial studied its use for looks. There are no data in men.
Effects
Evidence: Approved medicine — studied in people for its medical use
Sought effects by goal (as reported)
Possible side effects
Possible does not mean certain: whether they appear depends on dose, duration, individual response and monitoring. Below — what to watch for and how to notice it early.
13 possible side effects
level · how often it is reportedWhat the levels mean
Level: general category from the literature, not your personal risk
How often
- common
- reported often
- possible
- reported in some people
- rare
- reported occasionally
How to lower the risks
For 10 of 13 possible side effects there are specific ways to lower the chance: everyday measures, supplements and options a doctor may consider. For the rest — general advice. No measure removes a risk completely. Prescription medicines are listed only for a doctor to decide on, after tests — they have side effects of their own.
Check hormones before and after; if they stay low, see an endocrinologist.
How each option helps (7)
- Regular blood tests — LH, FSH and testosterone show how deep suppression is and whether natural production has recovered afterwards.
- Working with a doctor — Assesses how deep suppression is and guides recovery afterwards, including fertility testing.
- Clomiphene — A doctor may consider it after stopping, guided by hormone tests; recovery after long use can still take months. Risks: vision changes, mood swings, rare clots. Has side effects of its own.
- Human chorionic gonadotropin (hCG) — A doctor may consider it to preserve fertility (in men it keeps the testes working); it does not restart the pituitary, so natural LH still has to recover. Risks: higher estradiol, gynecomastia. Has side effects of its own.
- Tamoxifen — A doctor may consider it after steroids are stopped, guided by hormone tests; it has not been tested for this after steroid use. Risks: blood clots, vision changes. Has side effects of its own.
- Follicle-stimulating hormone (follitropins, menotropins) — A fertility doctor may consider adding it to hCG when semen tests and FSH stay low; it does not restart the pituitary. Risks: gynecomastia, acne. Has side effects of its own.
- Toremifene — A doctor may consider it after steroids are stopped, guided by hormone tests; it raised testosterone in subfertile men but was never tested after steroids. Risks: QT prolongation, clots. Has side effects of its own.
Avoid combining several oral steroids; regular cardio, soluble fiber (psyllium), less saturated fat and alcohol; if LDL/ApoB stay high, a doctor may consider a statin. Omega-3 only lowers triglycerides.
How each option helps (12)
- Regular blood tests — A lipid panel with ApoB shows how far HDL has dropped and LDL risen — changes you cannot feel.
- Working with a doctor — Interprets lipids and ApoB and decides whether a statin or other therapy is warranted.
- Avoiding alcohol and other liver stressors — Alcohol raises triglycerides; its small HDL bump does not lower heart risk.
- Regular cardio training — Raises HDL a little and lowers triglycerides; it cannot offset a steroid-driven fall in HDL on its own.
- Berberine — Placebo-controlled meta-analysis: LDL about 0.5 and triglycerides about 0.4 mmol/L lower; HDL unchanged. Trials are mostly small; no statin substitute.
- Citrus bergamot — Pooled small trials show lower LDL and triglycerides, but certainty is low to very low; it is no replacement for statins.
- Omega-3 (fish oil, EPA/DHA) — Clearly lowers triglycerides but does not fix the steroid HDL drop, the main lipid harm; DHA-containing oils may even raise LDL slightly.
- Psyllium husk fiber — Lowers LDL by about 0.2–0.3 mmol/L (roughly 5–10%), also on top of doctor-prescribed statins; no effect on HDL.
- Atorvastatin — A doctor may consider it when LDL or ApoB stay high; it strongly lowers them but barely lifts steroid-lowered HDL. Risks: muscle aches, drug interactions, rarely muscle or liver injury. Has side effects of its own.
- Rosuvastatin — A doctor may consider it when LDL or ApoB stay high; it strongly lowers them but barely lifts steroid-lowered HDL. Risks: muscle aches, rarely muscle or liver injury, slightly higher diabetes risk. Has side effects of its own.
- Ezetimibe — A doctor may consider it when LDL stays high on a statin or a statin isn't tolerated; it lowers LDL moderately but does not raise HDL. Risks: rare liver-enzyme rises. Has side effects of its own.
- Pravastatin / pitavastatin (low-interaction statins) — A doctor may consider them when LDL is high and other statins aren't tolerated; they lower LDL moderately and barely lift HDL. Risks: muscle aches, slightly higher diabetes risk. Has side effects of its own.
Avoid controlling estrogen blindly; adjust only by blood tests with a doctor.
How each option helps (1)
- Regular blood tests — Testing ends guesswork use of aromatase inhibitors — prescription drugs that can push estrogen too low and harm joints, libido, mood and lipids.
Products obtained without a prescription are often fake, mislabeled or non-sterile, and there is no way to check at home. For legal supplements, look for third-party testing (Informed Sport, NSF).
What is unknown cannot be lowered, only avoided; tell your doctor what you have taken.
Strength and weight-bearing training, enough calcium and vitamin D from food, no smoking; with long-term use a doctor may order a bone density scan.
How each option helps (1)
- Calcium — With vitamin D it lowered stress fractures in female recruits; in older adults, supplement trials show weak and inconsistent effects on fractures.
Less salt, regular cardio, good sleep; home readings; a doctor if it stays high.
How each option helps (8)
- Home blood-pressure monitoring — Seated, rested readings on several days show your true BP; persistently high values are a signal to see a doctor.
- Regular cardio training — Regular aerobic training lowers resting BP by a few mmHg, more in people with high BP.
- Working with a doctor — Diagnoses persistent hypertension and prescribes treatment when needed.
- Avoiding alcohol and other liver stressors — Regular drinking raises blood pressure; cutting it out lowers it.
- Coenzyme Q10 — Inconsistent: some analyses show a small systolic drop in cardiometabolic disease, but a Cochrane review found no clinically meaningful effect.
- Magnesium — Meta-analysis of trials: about 2 mmHg lower systolic pressure on average.
- Omega-3 (fish oil, EPA/DHA) — Small drop of a few mmHg, mainly in people with untreated high blood pressure.
- Taurine — Meta-analysis of 20 small trials: about 4 mmHg lower systolic pressure on average.
Ketoconazole shampoo, minoxidil, a dermatologist early if you are prone to it.
How each option helps (1)
- Minoxidil (topical) — Slows thinning and regrows some hair; scalp itching and early temporary shedding are common, unwanted facial hair possible. Gains fade once stopped.
Sterile technique, never share needles, vials or pens; see a doctor for a hot, swollen site. If equipment was ever shared, test for HIV and hepatitis B/C and ask about hepatitis B vaccination.
Stop at the first voice change and see a doctor — early stopping matters.
How each option helps (1)
- Working with a doctor — Steroid labels say to stop at the first mild signs (hoarse voice, facial hair, clitoral growth) to prevent permanent change; checks catch them early but do not make use safe.
Low-level side effects
How each option helps (3)
- Adapalene — Reduces spots in many users. Redness, scaling, dryness and stinging are common early and usually ease; acne may look worse at first. Rarely, allergic swelling.
- Benzoyl peroxide — A first-line acne option. Dryness, redness and peeling are common at first; it bleaches hair and fabric; rarely, serious allergic reactions. Severe steroid acne needs a dermatologist.
- Zinc — Trials show a modest drop in inflamed spots, weaker than antibiotics; steroid acne is driven by androgens.
How each option helps (5)
- Avoiding alcohol and other liver stressors — Removes a major extra liver stressor during oral steroids and other hepatotoxic drugs.
- Regular blood tests — ALT, AST, GGT and bilirubin show liver strain before symptoms; heavy lifting alone raises AST/ALT for days, and GGT helps tell muscle from liver.
- Ademetionine (SAMe) — Used for intrahepatic cholestasis in some countries, but trials are small and of low quality; untested in steroid users. Stopping the oral steroid matters most.
- N-acetylcysteine (NAC) — Restores glutathione; proven in paracetamol poisoning and helped in early acute liver failure of other causes, but untested in steroid users.
- TUDCA (tauroursodeoxycholic acid) — Improves bile flow in cholestatic disease; in steroid cholestasis only case reports, with failures in severe cases. Stopping the oral steroid matters most.
How each option helps (5)
- Sleep hygiene — A steady routine and no late caffeine ease stimulant- and steroid-related insomnia; night sweats on trenbolone persist regardless.
- Glycine — Small trials show slightly better sleep quality and less next-day fatigue; not a sedative and not for anxiety.
- L-theanine — Small gain in subjective sleep quality; effects on anxiety are inconsistent. May smooth caffeine jitters but won't offset strong stimulants like clenbuterol.
- Magnesium — Three small, low-quality trials in older adults: falling asleep about 17 minutes sooner. No good data in athletes.
- Melatonin — Helps you fall asleep a little faster, especially with a shifted body clock; does not treat anxiety or night sweats.
Check-ups and blood tests
Which tests and check-ups to do and when. This is a guide — agree the exact schedule with your doctor.
Which doctors can help
At home
- Home blood pressure: 2–3 times a week in the morning, keep a log
Get medical help at once if
- Sudden severe headache, vision changes, numbness or weakness on one side, trouble speaking — call emergency services.
- A hot, red, swollen or pus-filled injection site with fever — signs of an abscess; see a doctor.
- Deepening voice, new facial hair, clitoral enlargement — stop and see a doctor: changes can become permanent. (women)
In an emergency, call your local emergency number.
For women
Most users are women. Acne, excess hair, voice change and clitoral enlargement can appear, and voice and clitoral changes may be permanent. It often stops periods and markedly lowers HDL. Not for use in pregnancy: androgens can masculinize a female fetus.
Myth & fact
“The 'beauty chip' burns fat and only tones muscle.”
No trial studied it for looks. In medical trials most studies found weight gain, androgenic effects such as acne and excess hair were common, and WADA lists it as an anabolic agent.
Combinations
No specific combination notes for this substance yet. The stack check still adds up side effects that several substances share.
Sources
Possible side effects by body system, combinations, how to lower the risks and which tests to do — free.
Open the stack check